A comprehensive nootropic stack combining synaptogenesis, anxiolysis, BDNF upregulation, and cellular energy for peak cognitive performance.
This comprehensive nootropic capsule represents a multi-pathway approach to cognitive optimization, combining four research compounds with distinct and complementary mechanisms. Dihexa (PNB-0408) is an angiotensin IV analog reported to be approximately 10 million times more potent than BDNF at promoting synaptogenesis in the hippocampus. Selank is a heptapeptide analog of tuftsin developed at the Institute of Molecular Genetics in Russia, where it received regulatory approval for the treatment of anxiety disorders; it modulates GABAergic and serotonergic systems while also upregulating BDNF. Semax is a synthetic analog of ACTH(4-7) developed in Russia, where it is approved for use in stroke and cognitive impairment; it directly upregulates BDNF and NGF while activating dopaminergic and serotonergic pathways. NAD+ (nicotinamide adenine dinucleotide) is a fundamental coenzyme involved in over 500 enzymatic reactions, with particular importance in mitochondrial energy production and sirtuin-mediated gene regulation. Together, these four compounds address synaptogenesis, anxiolysis, neurotrophic factor upregulation, and cellular bioenergetics simultaneously.
* Benefits based on preclinical/animal research unless otherwise noted.
Dihexa promotes synaptogenesis by potentiating HGF/c-Met receptor signaling, activating PI3K/Akt and MAPK/ERK pathways that drive dendritic spine growth and long-term potentiation. Selank modulates GABA-A receptor function to reduce anxiety and promote alpha-wave brain activity, while simultaneously upregulating BDNF expression in the hippocampus and cortex. Semax acts as an ACTH analog that directly stimulates BDNF and NGF synthesis, activates dopamine D1/D2 receptors, and has demonstrated neuroprotective effects against ischemic and oxidative damage. NAD+ serves as a substrate for sirtuin deacetylases (SIRT1-7) that regulate mitochondrial biogenesis, DNA repair, and cellular stress responses; it also supports the electron transport chain for ATP production. The combination provides a comprehensive cognitive enhancement profile: structural (synaptogenesis via Dihexa), functional (neurotransmitter modulation via Selank/Semax), and bioenergetic (mitochondrial support via NAD+).
Protocol Notes: Morning dosing preferred. Use in cycles to prevent tolerance. Particularly valuable for high cognitive demand periods.
Store at room temperature, away from light.
When sourcing Dihexa + Selank + Semax + NAD+ (Capsule) for research purposes, the following quality benchmarks should be verified before use.
Store at room temperature, away from light.
The statements made within this website have not been evaluated by the US Food and Drug Administration. The products and information provided are not intended to diagnose, treat, cure, or prevent any disease. This website is intended for educational and research purposes only. Many peptides described on this site are not approved by the FDA for human therapeutic use and are classified as research chemicals. Nothing on this site constitutes medical advice.
Preliminary Evidence — Early-stage research only. Significant uncertainty about efficacy and safety in humans.
Peptides commonly used alongside Dihexa + Selank + Semax + NAD+ (Capsule) for synergistic effects.
Mitochondrial Electron Carrier
A century-old mitochondria-targeting compound that acts as an electron carrier to improve ATP production and cognitive function.
Learn More: Methylene Blue (Capsule)Angiotensin IV Analog / Nootropic
An angiotensin IV analog reported to be 10 million times more potent than BDNF at promoting synaptogenesis.
Learn More: Dihexa (Capsule)